Supplements
The Longevity Cheat Sheet
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Alpha-ketoglutarate (AKG) is a naturally occurring molecule and a popular supplement driven by bodybuilders seeking more ways to bulk up. AKG enhances athletic performance, supports muscle recovery, promotes overall energy levels, and supports weight loss. Outside of athletic performance, it benefits immune health, bone density, and gut health. In your cells, it helps drive the Krebs cycle in the mitochondria, provides amino acids for protein production, is an epigenetic modifier, and is crucial for collagen production.
Dosage: 500–1000 mg/day
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The aloe plant, Aloe barbadensis Miller, contains multiple key compounds including Naringenin, Emodin, Hyaluronic acid, Catalase, Superoxide dismutase, Peroxidase, and 7 out of the 8 essential amino acids. It is a potent antioxidant, anti-inflammatory, and can lower blood sugar levels. It is especially helpful for skin, known for soothing, healing, and moisturizing properties. Used both topically and orally, it increases skin collagen and hyaluronic acid production. Aloe also supports bone health and weight loss.
Dosage: 5000–10000 mg/day
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Alpha Lipoic Acid (ALA) is a naturally occurring compound that is an epigenetic modifier, promotes mitochondrial activity, supports healthy blood sugar levels, and improves the body's antioxidant defenses. Evidence shows ALA can improve learning and short-term memory (in rodents), enhance eyesight quality, and increase bone density. In people with diabetes, it counteracts peripheral neuropathy, reduces blood pressure, and improves nerve functionality.
Dosage: 300–600 mg/day
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Andrographolide, from Andrographis paniculata, is a traditional folk medicine for managing inflammation, arthritis, and treating sore throat or upper respiratory infections. It is a labdane diterpenoid, free radical scavenger, potent anti-inflammatory, and boosts natural defense mechanisms. The molecule benefits the GI tract, bone, and especially the brain, able to cross the blood–brain barrier.
Dosage: 400 mg/day
Recommended products
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Apigenin, notably found in chamomile tea, has been used for centuries—ancient Egyptian hieroglyphs show its use for skin beautification, healing, and fever reduction. Apigenin offers DNA protection, epigenetic modulation, immunomodulatory, and anti-inflammatory effects.
Dosage: 50 mg/day (formulation dependent)
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